Research Experiment: Homeopathic Remedies Prevent Dye-induced Liver Cancer in Mice

An older study using two homeopathic remedies to determine if they could stop or prevent the growth of cancerous tumors previously induced in mice showed a very positive result for the homeopathic remedies versus placebo.
Here are the details of the study:
Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741 235, India.

Indian journal of biochemistry & biophysics (Impact Factor: 0.87).08/2009; 46(4):307-18. Source: PubMed

ABSTRACT

The study was undertaken to examine whether Carcinosin-200 (Car-200- [a homeopathic remedy]) could provide additional ameliorative effect, if used intermittently with Natrum sulphuricum-30 (Nat Sulph-30- [a homeopathic remedy]) against hepatocarcinogenesis induced by chronic feeding of p-dimethylaminoazobenzene (p-DAB) and phenobarbital (PB) in mice (Mus mnusculus). Mice were randomly divided into seven sub-groups: (i) normal untreated; (ii) normal + succussed alcohol; (iii) p-DAB (0.06%) + PB (0.05%); (iv) p-DAB + PB + succussed alcohol, (v) p-DAB + PB + Nat Sulph-30, (vi) p-DAB + PB + Car-200, and (vii) p-DAB + PB + Nat Sulph-30 + Car-200. They were sacrificed at 30, 60, 90 and 120 days for assessment of genotoxicity through cytogenetical end-points like chromosome aberrations, micronuclei, mitotic index and sperm head anomaly and cytotoxicity through assay of widely accepted biomarkers and pathophysiological parameters. Additionally, electron microscopic studies and gelatin zymography for matrix metalloproteinases (MMPs) were conducted in liver at 90 and 120 days. Results showed that administration of Nat Sulph-30 alone and in combination with Car-200 reduced the liver tumors with positive ultrastructural changes and in MMPs expression, genotoxic parameters, lipid peroxidation, gamma-glutamyl transferase, lactate dehydrogenase, blood glucose, bilirubin, creatinine, urea and increased GSH, glucose-6-phosphate dehydrogenasc, superoxide dismutase, catalase, glutathione reductase activities and hemoglobin, cholesterol, and albumin levels. Thus, intermittent use of Car-200 along with Nat Sulph-30 yielded additional benefit against genotoxicity, cytotoxicity, hepatotoxicity and oxidative stress induced by the carcinogens during hepatocarcinogenesis.

Homeopathic drugs Natrum sulphuricum and Carcinosin prevent azo dye-induced hepatocarcinogenesis in mice (PDF Download Available). Available from: https://www.researchgate.net/publication/26854924_Homeopathic_drugs_Natrum_sulphuricum_and_Carcinosin_prevent_azo_dye-induced_hepatocarcinogenesis_in_mice

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New Scientific Model For Homeopathic Remedy Effects

Iris Bell, a holistic medical doctor, researcher and professor of medicine at University of Arizona, and Mary Koithan have proposed a new and intriguing method for how homeopathic remedies work. “This paper proposes a novel model for homeopathic remedy action on living systems. Research indicates that homeopathic remedies (a) contain measurable source and silica nanoparticles heterogeneously dispersed in colloidal solution; (b) act by modulating biological function of the allostatic stress response network (c) evoke biphasic actions on living systems via organism-dependent adaptive and endogenously amplified effects; (d) improve systemic resilience.”

Dana Ullman who has a Masters of Public Health and is a teacher of homeopathy comments: “This article is quite brilliant and very futuristic in verifying that homeopathy is a “nano-pharmacology.” When you consider that many hormones circulating in our body are in similar extremely small doses, homeopathy makes more and more sense…and heck, its results are amazing. There are good reasons that more educated people use homeopathics than those who don’t.”

Summary

Homeopathic remedies are proposed as source nanoparticles that mobilize hormesis and time-dependent sensitization via non-pharmacological effects on specific biological adaptive and amplification mechanisms. The nanoparticle nature of remedies would distinguish them from conventional bulk drugs in structure, morphology, and functional properties. Outcomes would depend upon the ability of the organism to respond to the remedy as a novel stressor or heterotypic biological threat, initiating reversals of cumulative, cross-adapted biological maladaptations underlying disease in the allostatic stress response network. Systemic resilience would improve. This model provides a foundation for theory-driven research on the role of nanomaterials in living systems, mechanisms of homeopathic remedy actions and translational uses in nanomedicine.

A model for homeopathic remedy effects: low dose nanoparticles, allostatic cross-adaptation, and time-dependent sensitization in a complex adaptive system Iris R Bell and Mary Koithan- BMC Complementary and Alternative Medicine 2012, 12:191 doi:10.1186/1472-6882-12-191-Published: 22 October 2012